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Reed MC, Nijhout HF, Neuhouser ML, Gregory JF, Shane B, James SJ, Boynton A, Ulrich CM: A Mathematical Model Gives Insights into Nutritional and Genetic Aspects of Folate-Mediated One-Carbon Metabolism

Gut 71 , 22842299 (2022)

Free radicals are a natural byproduct of energy production in the cells, but they also enter the body through pollution, UV radiation, and processed foods

But given that these side effects are very rare, taking vitamin B12 at bedtime should be fine unless sleep disruption becomes a persistent symptom after taking supplements

To get the most benefit, try to eat glutathione-rich fruits and vegetables raw or very lightly steamed