van Dam DG, Beijers AJ, Vreugdenhil G
For years, people with type 2 diabetes have relied on a synthetic version of the hormone, called a GLP-1 agonist, to help them manage their symptoms and maintain normal blood sugar levels
TCF7L2 is a possible regulator of GLP-1 receptor expression in human vascular cells Since there was correlation between the expression levels of GLP-1 receptor and TCF7L2 in the aorta in our experiments and it is well known that TCF7L2 is a transcriptional factor of GLP-1 receptor in pancreatic -cells, we hypothesized that TCF7L2 regulates GLP-1 receptor expression in human vascular cells as observed in -cells
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Most patients on either drug don't reach either extreme, but the distribution skews differently tirzepatide pulls the curve toward Depletive, semaglutide skews toward Prime