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SURMOUNT examined tirzepatide for weight management (NEJM, 2022)

The medications unique power lies in its ability to mimic the GLP-1 hormone, which effectively modulates key hunger and satiety signals in the brain and slows gastric emptying, leading to a sustainable reduction in caloric intake

Tirzepatide, the newest dual GLP-1/GIP receptor agonist, has a similar 5-day half-life, but limited data suggest potentially less gastric emptying delay compared to pure GLP-1 agonists due to dual receptor activation [30]

Insert one suppository and retain for 15-30 minutes if possible

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