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442 Preclinical studies have documented the inhibitory effects of GLP-1RAs on the development of AS in animal models

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However, the company has guided for accelerated generic erosion in Somatuline from mid-2025 onwards as additional generics enter the market in the US and Europe a headwind that will challenge revenue growth through the 20262028 period

Effects of exenatide once weekly plus dapagliflozin, exenatide once weekly alone, or dapagliflozin alone added to metformin monotherapy in subgroups of patients with type 2 diabetes in the DURATION-8 randomized controlled trial

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