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Other relevant factors include: Pre-existing conditions: Anaemia, hypothyroidism, sleep apnoea, and depression can all independently cause fatigue and may compound drug-related tiredness, making it harder to distinguish the cause
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Additionally, reduced stomach acid production in older adults limits B12 absorption from oral supplements
[3] Additionally, NAD+ has been investigated for improving metabolic health, possibly benefiting conditions like metabolic syndrome by supporting better insulin sensitivity and mitochondrial function
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