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The biological plausibility is strong
Average participant ages ranged from 7 to 50 years
Managing Side Effects and Optimizing Tolerability at the 10 mg Dose Common side effects intensify as tirzepatide doses increase, with nausea, vomiting, and constipation reported most frequently in clinical trials
"Zepbound Prior Authorization Resource Guide." zepbound.lilly.com Blue Cross Blue Shield of Michigan
However, as the GLP-1 albumin fusion and unfused albumin have the same theoretical pI, and only small differences in pH-dependent net charge, this probably does not explain the discrepancy between their FcRn binding properties and cellular handling or plasma half-life
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