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GHK-Cu's copper coordination complex can undergo structural rearrangement during freezing as ice crystal formation concentrates solutes and shifts local pH, potentially causing copper dissociation from the peptide and subsequent loss of biological activity upon thawing

Rochira, V., & Guaraldi, G

23 March 2017 Scientific Reports 7: Article number: 40815

GHK-Cu fills gaps that neither drug addresses: TGF-beta1 suppression, Wnt pathway support, collagen cross-linking for follicle structural integrity, and DPC anti-apoptosis