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Discontinuation Rates Clinical trial discontinuation rates due to adverse events are similar: Trulicity: 5-8% discontinuation due to adverse events Ozempic: 5-7% discontinuation due to adverse events Neither medication has a significant dropout advantage

One study, using objective instruments to measure some aspects of physical function, reported that GLP-1 medications significantly improved physical function compared to placebo

learning memory and exploration behavior are impaired, oxidative stress factor expression is changed, and mitochondria are damaged

It adds that kidney function, cardiovascular history, and prior medication tolerance should be assessed first