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Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
Many published models are derived from retrospective datasets, are vulnerable to confounding (e.g., baseline adiposity, illness severity, polypharmacy, and socioeconomic determinants), and can suffer from optimistic performance estimates due to data leakage, small sample sizes, and inconsistent outcome definitions
Patients commonly report reduced appetite, earlier satiety with smaller portions, and decreased food cravingseffects mediated through central appetite regulation in the hypothalamus
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