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Melanotan and Melanotan 2 are both analogues of the peptide hormone alpha-melanocyte stimulating hormone (-MSH) that tend to induce skin tanning
But many (most?) people still lose muscle mass while on it
In these studies, the safety profile of retatrutide was found to be on par with that of other incretin mimetics like tirzepatide [21, 27]
Regul Pept 2005
For example, certain GLP1R variants are associated with higher likelihood of robust weight loss at standard maintenance doses, while FTO variants relate to baseline appetite regulatory patterns
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