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Efforts to improve potency while retaining the optimal profile led to the most balanced Compound 77 , which combines a methyl-pyridine and methyl-1,3,4-thiadiazole motif, achieving high potency, selectivity, and favorable PK, making it a lead candidate for further evaluation

Yifeng Wang, Jibiao Li, David Matye, Yuxia Zhang, Katie Dennis, Wen-Xing Ding, Tiangang Li Disrupting enterohepatic bile acid recycling decreased hepatic glutathione in mice.

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It has been suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is involved in the induction of HO-1 expression by acetylcarnitine [18]

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