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Clinical studies on the dual GIP/GLP-1 receptor agonist, tirzepatide Tirzepatide has demonstrated significant weight loss effects in phase III clinical trials
Individual results will vary based on factors such as starting weight, diet, activity level, and overall health
The HFD feeding was suggested to induce HDAC3 activity, which was associated with increased body weight gain and blood glucose concentrations ( Figure 2 ), while supplementation with butyrate, a SCFA, was able to reduce weight gain in HFD fed mice, presumably via HDAC3 dependent mechanisms
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