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As shown in Figure 2 , following stimulation of GLP-1R by exenatide on microglia, the cAMP/PKA/p38/CREB signal transduction pathway is activated, promoting the expression of IL-10
Due to the limit of available articles at the time of search, the initial search was quite broad with a very narrow final evidence base which mainly resulted in case reports or case series, narrative scoping reviews, or small retrospective cohorts
By reducing reward sensitivity, Contrave can also help decrease cravings for sugar, refined carbohydrates, and calorie dense snacks
However, post-marketing surveillance and patient reports suggest that some individuals taking semaglutide do experience leg cramps during treatment
Ann NY Acad Sci 1018:533540
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