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Even in healthy controls without any supplementation blood glucose and insulin resistance correlate positively with NAD metabolites

Its efficacy is demonstrated through the reduction of liver fat, improvement of liver function markers, and regulation of specific genes such as Atf3 and Acox2, supporting its development as a targeted therapy (82)

The response to linsitinib is inferior to the topoisomerase inhibitor topotecan, with median progression-free survival of 3.0 (95% CI 1.53.6) and 1.2 (95% CI 1.11.4) months for topotecan and linsitinib, respectively [159]