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The inter-monomer hydrogen bonds were destabilized and water-mediated hydrogen bonds were more prominent in the mutated insulin dimer, which disrupted the anti-parallel -sheet formed by the C-terminus of the B-chain at the monomer-monomer interface, thereby decreasing the stability of the insulin dimer

Hsieh, M-J

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Sequence: Gly-His-Lys (complexed withCu+)

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