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Statements Acknowledgments The authors acknowledge financial support from Department of Science and Technology to PP and Department of Biotechnology to AVM
Various topical, oral, and injection-based cosmetic skin-lightening agents with different mechanisms of action are used widely across Asia, including hydroquinone, azelaic acid, kojic acid, mulberry, alpha-arbutin, beta-arbutin, glutathione, licorice root, papaya, vitamin A (e.g., retinol), vitamin B (i.e., niacinamide), and vitamin C
FDAs briefing said the criteria weighed against inclusion because of inconsistent substance naming, limited evidence, safety uncertainty and the availability of established treatments for the proposed conditions
Ishii (Organization of Advanced Science and Technology, Kobe University) for providing us with pGK402 and pGK405 plasmids
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