(PubMed) Sahebkar A, Simental-Mendia LE, Stefanutti C, Pirro M
Thiamine is necessary for maintaining intestinal epithelial cell bioenergetics, and reduced activity of thiamine-dependent enzymes may lead to a defective gut barrier (34)
Should metformin dose be increased first in a patient with type 2 diabetes mellitus, HbA1c 5.8%, taking metformin 500 mg daily, phentermine, and NP thyroid 60 mg daily, with poor diet and exercise compliance, before considering GLP-1 receptor agonists?
That means the highest drug concentration during the week is about 2.7 times the lowest concentration
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