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Decompression therapy can help alleviate symptoms associated with these conditions by gently stretching the spine and promoting disc hydration and nutrition
Additionally, LOXs (e.g., ALOX15) directly oxidize PUFAs into lipid hydroperoxides (PUFA-OOH), accelerating ferroptosis execution, a process that can be pharmacologically inhibited by LOX blockers like zileuton or mitigated through structural PUFA modifications such as bis-allylic deuteration 24
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