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Therefore, exposure to foreign antigens from the first stimulus or to EBV viral antigens leads to activation of CD4 T cells and IFN- release, provided that the cells presenting these antigens to CD4 T cells are not previously infected with EBV, since the gp42HLA-II complex in these cells would prevent their activation [171, 194]

However, we did not have information of the disease severity at the sampling time (Supplementary Table 6, Fig