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Unlike genetic resistance, these phenotypes enable fungal cells to survive high concentrations of antifungals without a measurable increase in minimum inhibitory concentration (MIC), contributing to chronic and relapsing infections ( Cryptococcus can enter a quiescent state that confers high tolerance to AmB (Ke et al., 2024)

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124 SAT1, a rate-limiting enzyme in polyamine catabolism, has been identified as a transcription target of p53

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