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Pillar 6: Pioglitazone (PPAR-gamma agonist) Pioglitazone can improve insulin sensitivity partly by redistributing fat away from ectopic depots (liver and muscle) towards safer subcutaneous stores

Additionally, aged keratinocytes fail to induce MMPs and other proteases required to successfully migrate through the wound granulation tissue [155]

Modulation of Growth Factors: This peptide interacts with various growth factors in the body, such as VEGF (Vascular Endothelial Growth Factor), which further supports tissue repair and regeneration

Human evidence is limited and largely cosmetic

[30] This guidance remains relevant, if not more so, during treatment with agents that affect the gastrointestinal tract