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Navarro-Gonzalez JF, Sanchez-Nino MD, Donate-Correa J, et al

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Metformin inhibits advanced glycation end products-induced inflammatory response in murine macrophages partly through AMPK activation and RAGE/NFB pathway suppression

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These interactions modify the equilibrium between bone creation and resorption, thereby influencing the development of OP (97, 98)

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