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Systemic administration of the neurotensin NTS-receptor agonist PD149163 improves performance on a memory task in naturally deficient male brown Norway rats
Clinical trials have utilized doses ranging from 1 mg per day up to 30 mg per day in divided doses for various administration routes
Those dates help place the result in time
The release of sonic hedgehog (SHH) by astrocytes acts on ECs to modulate TJ protein expression and maintain BBB integrity (Daneman and Prat, 2015
This system mediates neuroprotection, synaptogenesis, cerebral blood flow, long-term potentiation and memory consolidation and retrieval
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