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Follow all applicable laboratory safety protocols and institutional regulations

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TRIUMPH-4 (NCT05931367, 68 weeks, obesity and knee osteoarthritis): 28.7% average weight loss on 12mg versus 2.1% on placebo

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Nutritional status : Given that Crohn's disease can cause malnutrition and that Saxenda promotes weight loss, careful assessment of nutritional adequacy is essential

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Furthermore, no meta-analysis has included all relevant RCTs to assess the cancer risk associated with tirzepatide

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