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F., de Oliveira, V
Approximately 10% of energy-controlling gene expression, including those encoding nuclear hormone receptors and glucose and lipid metabolism enzymes, are regulated by circadian rhythm in a tissue-specific manner (Storch et al., 2002
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Furthermore, BEC is a slow-binding inhibitor of arginase, which is still in the preclinical stage (Pudlo et al., 2017)
Interestingly, the addition of the free radical scavengers allopurinol (an inhibitor of xanthine oxidase, an enzyme known to generate superoxide radicals), superoxide dismutase and dimethyl sulfoxide (a hydroxy radical scavenger) resulted in a significant reduction of PGN-induced lesions in rats (Moyana and Lalonde 1990b Moyana, T
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