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Patients with T2D not adequately controlled on therapy with metformin and insulin glargine as baseline therapy received either tirzepatide at the doses used in the SURPASS trials or placebo during the 40-week study setting
High-energy diets, though promoting follicular growth through elevated insulin, paradoxically impair oocyte quality, indicating unresolved links between metabolic signaling and oocyte competence ( 5.1.2 Clinical heterogeneity Clinical translation is hindered by variability in diagnostic and dosing frameworks
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3436 Another meta-analysis of 49 randomized controlled trials found that thiazolidinediones (especially pioglitazone [Actos]) improved steatosis and inflammation but were associated with a weight increase of 4.5 to 11 lb (2 to 5 kg) in 66% to 75% of patients and edema in 4% to 10% of patients
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