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The performance and financial cost of extended absence create motivation to explore off-label options despite regulatory and safety uncertainties
Global knockout of the GLP-1R produces no body weight or food intake phenotype in chow-fed mice (Scrocchi et al., 1996)
A C20 fatty diacid moiety is attached to the lysine residue at position 17 via an AEEA-Glu linker, enabling albumin binding and extended pharmacokinetic half-life
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