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These effects were mediated by reduction in islet cAMP concentration, as demonstrated by experiments in vitro in isolated Sur1 -/- mouse islets ( ATP channels where consumption of protein leads to insulin secretion and hypoglycemia ( The findings from mouse islets, have been replicated in human islets isolated from the pancreas of infants with diffuse K ATP hyperinsulinism
Keep up with new research to see how triple-agonist drugs could transform treatment for diabetes and obesity
PMID: 2677641
But this isnt only due to tolerability concerns
Geier, J.B
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