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After symptoms abate, the recommended dose is 100 mcg monthly, for life
That means that not only are vitamin B12 levels the same across those with and without hair loss, but that for those with hair loss, vitamin B12 supplementation generally doesnt improve hair loss outcomes
The peptide works best as part of a comprehensive approach including proper nutrition, regular exercise, and lifestyle optimization rather than as a standalone intervention
Oral supplements, due to their lower absorption rates, often require weeks or months to produce similar results
A companion mechanistic paper, Chang et al., Molecules 2014, found that the peptide up-regulated growth-hormone-receptor expression in tendon fibroblasts at both mRNA and protein levels, potentially sensitising these cells to growth hormone during repair
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