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AMINO-1MQ (5-Amino-1MQ) NNMT Inhibitor Research Compound AMINO-1MQ (5-amino-1-methylquinolinium) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) , an enzyme involved in cellular methylation and NAD+ metabolism
For example, cancer cells upregulate the expression level of the PPP [26] , NRF2 [52] , and isocitrate dehydrogenase 1 (IDH1) [48] as backup mechanisms for NADPH production
tannins and polyphenols in coffee, tea, and red wine) or enhance (vitamin C) its absorption when consumed in the same meal [59]
