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The timing of administration is critical and usually occurs when ultrasound monitoring shows that the egg is mature
Vollmer DL, West VA, Lephart ED
But, insufficiency isnt as bad as frank deficiency, which can manifest in cases like cerebral atrophy, meaning brain shrinkage, in a Vitamin B12-deficient Infant of a Vegetarian Mother. Thankfully, even severe brain atrophy can be substantially reversed with B12 supplementation, but better not to become deficient in the first place
Mori H, Kuroda A, Ishizu M, Ohishi M, Takashi Y, Otsuka Y, et al
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