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In its recent evaluation, the EFSA Panel on contaminants took note of the very low levels of the principle OTA adduct in rat kidney (reported range 2070 10 9 nucleotides) and stated: It remains unclear whether and to what extent these DNA adducts are formed in vivo and which metabolic pathway(s) are responsible for the formation (EFSA 2020)
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Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
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