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Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with obesity without type 2 diabetes mellitus: a randomized dose-ranging study

Phiel et al

Sirni P, Vyrynen JP, Klintrup K, Mkel J, Karhu T, Herzig K-H, et al

this is more of a supportive measure than an interaction concern

This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)