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following a major trauma resulting in gram-negative sepsis and multi-organ failure (MOF), or gradually leading to chronic inflammatory diseases
It is prolonged, cumulative exposure that causes measurable degradation
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Spectroscopic and computational studies of cobalamin species with variable lower axial ligation: Implications for the mechanism of CoC bond activation by class I cobalamin-dependent isomerases
it was a philosophical foundation suggesting that no substance is inherently a poison or a remedy
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