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It also indirectly inhibits bone resorption through calcitonin release from thyroid C-cells
These formulations are particularly preferred for chronic management of obesity, as they ensure higher bioavailability compared to oral alternatives and allow the use of long-acting, once-weekly or once-daily therapies
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Large-scale clinical trials have demonstrated that GLP-1RAs predominantly exhibit neutral or suppressive effects on overall cancer risk, with semaglutide showing no elevated cancer incidence [14], while significant reductions have been observed in specific malignancies, particularly liver cancers and prostate cancers [13, 15]
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