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Factors such as individual metabolism, dosage, and whether the medication is taken with or without food can influence when symptoms appear
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Obesity (Silver Spring, Md.), 10.1002/oby.24331
Stacking agents can amplify adverse effects, especially insomnia, palpitations, and nausea
Semaglutide trials (SUSTAIN and PIONEER series) reported nausea in 20-40% of patients depending on the dose and formulation, with oral versions showing slightly higher rates than injections
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