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Methionine research primarily comes from animal models examining liver triglyceride regulation

Histologically, the lesion is composed of spindle cells in a collagenous myxoid stroma and the cells showed S-100 protein positive

The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months

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