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"Patients may not realize the risks associated with losing lean mass

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In addition to their peripheral actions, GLP-1Rs are also expressed throughout the central nervous system, particularly within hypothalamic nuclei, septal regions, the brainstem and at lower levels in various cortical structures (Pyke et al., 2014

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These people may need direct supplementation with methylcobalamin or adenosylcobalamin rather than cyanocobalamin

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