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Kline is a board-certified family medicine physician and co-founder of Trinity Family Medicine

Recent studies on the effects of HDAC and DNMT inhibitors in AUD mouse models have shown that treatment with the DNMT inhibitor decitabine results in decreased ethanol drinking and upregulated expression of genes highly represented in oligodendrocytes and astrocytes in the ventral tegmental area, key region in the brain reward pathways (Ponomarev et al., 2017)

Visible fat usually comes off first, but visceral fat remains, which slows metabolic improvement

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