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Sci Rep 15 , 4947 (2025)
Upon activation of the GLP-1 receptor, cAMP levels increase, which activates the cAMP response element-binding protein (CREB) ( Furthermore, GLP-1R activation increases cAMP and alters downstream signaling pathways, including PKA, PI3K, PKC, and AKT, all of which contribute to its neuroprotective effects (Zhou et al., 2019)
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This is a side effect to monitor as more Phase 3 data becomes available, though it does not appear to be a major tolerability concern based on the initial data
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