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Guided by sgRNA, Cas9 can precisely locate any specific genomic region and function as molecular scissors to generate a double-strand break (DSB) (Fig

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This sounds significant until you understand the context: baseline GLP-1 secretion is transient and rapidly degraded, with a circulating half-life of 1-2 minutes due to DPP-4 enzyme activity 24 Deacon, C.F

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