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Future work will use longitudinal profiling and single-cell sequencing to assess cell-type-specific GSH roles 5 Conclusion In conclusion, by leveraging multi-omics integration, the present study identified GSH metabolism as a pivotal node in SAE, while providing a comprehensive molecular framework for SAE pathogenesis, and linking microglia-driven neuroinflammation to hippocampal oxidative damage
Dnmts and Tet enzymes mainly maintain DNA methylation and demethylation patterns 41
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Clinical studies show that kojic acid can reduce melanin synthesis by up to 80%, which translates to visible lightening of dark spots and overall skin tone
