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In regard to mediating energy or glucose homeostasis, neurons of the myenteric plexus of the ENS are activated via duodenal glucose infusion 71 and by hormones released in response to nutrient sensing in the gut, such as GLP-1 from EECs and serotonin (5-HT) from enterochromaffin cells (ECs) 71,72,73,74
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Comprehensive reviews describe BPC-157 within the broader framework of cytoprotection in the gastrointestinal tract and beyond (Sikiric 2019, review)
Wegovy was recently approved by the FDA to treat weight loss for individuals with a BMI of 30 or higher (considered the obese category) and individuals with an overweight BMI (25 - 30) who also have a weight-related comorbidity (high blood pressure, high cholesterol, fatty liver disease, etc.)
For example, some people taking GLP-1 medications have reported digestive tract side effects such as nausea, vomiting, and diarrhea
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