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The challenge is that the proportion of chromosomally normal eggs decreases with age, which is why older women may need more IVF cycles to find a healthy embryo

Endocrinology and Metabolism , 58(3), 219-232

Concurrently, PYY (1-36) activates the Y1 receptor to regulate the expression of apoptosis-related genes (e.g., Bcl2, Nfkb1) and proliferation-related genes (e.g., Crebp), thereby promoting -cell proliferation and protecting -cells from damage caused by stressors such as STZ, high-sugar, and high-fat diets (113, 114)

None were already taking diabetes medicines, while all had inadequately controlled blood-sugar levels and BMIs of at least 23

Jun 2018;26(6):977-984