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Eli Lilly's Phase 3 obesity programme for retatrutide (master protocol J1I-MC-GZBJ) remains in active follow-up with no NDA (New Drug Application) or MAA (Marketing Authorisation Application) filing recorded in 20242026 pipeline disclosures [1][2]
However, tirzepatide does not directly target liver fat oxidation the way survodutide does
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We have to think about whether the speed of weight loss and the amount of weight loss are the right way to approach obesity in every case. Kyle pointed to modern reinterpretations of the Minnesota Starvation Experiment, which showed that regain often exceeds baseline weight and disproportionately as fat mass
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