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The complexity of DPP4 action stems from (i) a long list of substrates cleaved by the enzyme including hormones, growth factors, and cytokines, (ii) an additional function of this protein being a binding partner at the surface of different cells, specifically immune cells, and (iii) the recent discovery that DPP4 is an adipokine with different endocrine functions
Focus on health, energy, and sustainability
Their rapid adoption underscores just how quickly the treatment paradigm has shifted
You stand to lose more fat than through diet and exercise alone
Genetics and receptor sensitivity Individual variation in GLP-1 receptor expression, density, and sensitivity creates a genetic component to treatment response
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