Patients should contact their GP or diabetes specialist nurse urgently if they experience: Widespread or severe itching that affects multiple areas of the body or significantly impacts quality of life and sleep Accompanying rash, hives (urticaria), or skin changes such as blistering, peeling, or discolouration Swelling of the face, lips, tongue, or throat , which may indicate angioedema Difficulty breathing, wheezing, or chest tightness , suggesting a potential anaphylactic reaction Persistent itching at injection sites that does not resolve within a few days or worsens over time Signs of infection at injection sites, including increased warmth, pus, or spreading redness Itching with yellowing of the skin or eyes (jaundice) , dark urine, pale stools, or right upper abdominal pain, which could indicate gallbladder or liver problems Anaphylaxis is a rare but serious hypersensitivity reaction that requires immediate emergency care

Moreover, the abundance of free radicals leads to increased oxidative stress, an accelerator and hallmark of aging tied to a myriad of age-related diseases
7 Effects of highly palatable and high-fat/high-sugar foods versus non-food objects on brain activation at week 6 as assessed by BOLD fMRI
Hair loss concerns are less documented with retatrutide than with some other GLP-1 agonists, but the rapid weight loss itself can trigger telogen effluvium, a temporary shedding condition
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