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The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results trial (LEADER) led to a paradigm shift in the wider use of GLP-1RA from promising antihyperglycemic agents to cornerstone cardiometabolic therapies, demonstrating the significant reduction of major adverse cardiovascular events (MACE) with the use of liraglutide in the population with type 2 diabetes mellitus (T2DM) [12, 13]

Hong H, Johnson P

The top quartile of responders saw increases of 51%

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2018, doi: 10.1016/S0140-6736(18)32260 Ceriello, S