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Importantly, no dose adjustments are required for patients with renal impairment, including those with severe CKD or end-stage renal disease, though clinical experience in patients on dialysis is more limited

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Log-phase Mtb cultures were subjected to nutrient starvation in Middlebrook 7H9 broth lacking albumin, dextrose, and sodium chloride (ADS) or any additional carbon source, and supplemented with tyloxapol, a non-metabolisable detergent, to prevent bacterial clumping