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The next frontier in GLP-1 drug development GLP-1 medications have already reshaped obesity management, but research pipelines suggest that what we have today is just the beginning
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References Alkabbani, W., Zongo, A., Minhas-Sandhu, J
The Liraglutide Effect and Action in Diabetes (LEAD)-3 trial included 746 adults (age up to 79 years) with T2D randomised to liraglutide, 1.2 or 1.8 mg, or glimepiride, and found that weight loss following liraglutide did not adversely impact bone mineral density [90], although we do not have data for the impact of liraglutide at 3 mg
This is relevant because it separates matrix-synthesis observations from simple cell-proliferation explanations within that experimental context
